Tolperisone

Tolperisone: A Centrally Acting Muscle Relaxant

Tolperisone, known by the trade name Mydocalm among others, is a centrally acting skeletal muscle relaxant prescribed for the treatment of increased muscle tone and spasms associated with neurological diseases. This article provides an overview of Tolperisone, including its use, pharmacology, history, and safety profile.

Introduction

Tolperisone pill, commonly known by its trade name Mydocalm.

Tolperisone is a medication used to alleviate symptoms of muscle spasticity and hyperreflexia. Since its introduction in the 1960s, it has been utilized in various neurological conditions to improve mobility and reduce muscle stiffness.

Clinical Use

Tolperisone is indicated for the treatment of pathologically increased tone and spasms of skeletal muscles resulting from neurological disorders such as multiple sclerosis, chronic myelopathy, cerebral palsy, and stroke. It is also used for spastic and muscle-tonic syndromes, as well as for rehabilitation after orthopedic and trauma surgery.

Pharmacology

Tolperisone modulates neurotransmission to produce muscle relaxation.

Mechanism of Action

Tolperisone acts on the central nervous system (CNS) and has a multimodal mechanism of action. It is thought to inhibit voltage-gated sodium and calcium channels, which leads to a reduction in spinal reflexes and decreased muscle tone.

Absorption and Metabolism

Tolperisone is well absorbed after oral administration and is metabolized in the liver. It has a relatively low potential for drug-drug interactions, making it a suitable option for patients on multiple medications.

History

Since its synthesis and pharmacological characterization in the 1960s, Tolperisone has been extensively used in Europe and Asia. Research has been focused on its therapeutic effects and safety profile, solidifying its place in the treatment of spasticity.

Safety and Side Effects

The safety profile of Tolperisone is favorable, with most side effects being mild and transient. Common side effects include headache, nausea, and low blood pressure. However, it is contraindicated in patients with myasthenia gravis and should be used with caution in those with impaired liver function.

Conclusion

Tolperisone remains an important agent in the management of spasticity and muscle tension associated with neurological conditions. Ongoing research continues to refine its clinical applications and safety profile.

Tolperisone Resources
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