Treatment of Rett syndrome

Tiomesterone is a synthetic, orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of testosterone that was never marketed. It is a designer steroid and has been used in bodybuilding. Tiomesterone has been found to be well-absorbed from the gastrointestinal tract, but its oral bioavailability is low due to extensive first-pass metabolism in the liver.

Pharmacology

As an AAS, tiomesterone is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women.

Chemistry

Tiomesterone, also known as 17α-methyl-δ1-testosterone or as 17α-methylandrost-1,4-dien-17β-ol-3-one, is a synthetic estrane steroid and a derivative of testosterone. It is specifically a derivative of methyltestosterone, which is testosterone with a methyl group at the C17α position.

Side Effects

The side effects of tiomesterone are similar to those of other AAS. These may include acne, seborrhea, increased body/facial hair growth, scalp hair loss, voice changes (deepening), increased libido, frequent or persistent erections, and more rarely, liver damage, cardiovascular disease, and behavioral changes (increased aggression).

See Also

• List of androgens/anabolic steroids
• List of androgen esters

References

Treatment of Rett syndrome Resources
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