Trimethyltryptamine

Trimethyltryptamine (TMT) is a naturally occurring psychedelic compound of the tryptamine family. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. TMT is used for various spiritual and shamanic purposes, including divination and healing.

Chemistry[edit | edit source]

Trimethyltryptamine is a derivative of the naturally occurring amino acid tryptophan. It is structurally similar to the neurotransmitter serotonin and the psychedelic psilocybin. TMT is a white, crystalline substance that is usually consumed by smoking or vaporizing.

Pharmacology[edit | edit source]

TMT acts primarily as a serotonin receptor agonist, meaning it mimics the action of serotonin in the brain. It has a particularly high affinity for the 5-HT2A receptor, which is thought to be the primary target of psychedelic drugs. TMT also has some affinity for the sigma-1 receptor, which may contribute to its psychedelic effects.

Effects[edit | edit source]

The effects of TMT are highly dose-dependent and can range from mild visual distortions to intense hallucinations and mystical experiences. Users often report feelings of euphoria, deep introspection, and a sense of connection with the universe. The effects typically last for about 30 minutes to an hour.

Safety[edit | edit source]

While TMT is not considered physically addictive, it can be psychologically habit-forming. There is also a risk of adverse psychological reactions, such as anxiety and paranoia, especially at high doses or in individuals with pre-existing mental health conditions.

Legal status[edit | edit source]

The legal status of TMT varies by country. In the United States, it is classified as a Schedule I controlled substance, meaning it is illegal to manufacture, distribute, or possess.