Ubiquitin-fold modifier conjugating enzyme 1

Ubiquitin-fold modifier conjugating enzyme 1 (UFC1) is a protein that in humans is encoded by the UFC1 gene. The UFC1 protein is a member of the ubiquitin-conjugating enzyme family and is involved in a variety of cellular processes, including protein degradation, DNA repair, and cell cycle regulation.

Function

UFC1 is a enzyme that catalyzes the covalent attachment of ubiquitin-like proteins (UBLs) to target proteins. This process, known as ubiquitination, is a key regulatory mechanism in many cellular processes. UFC1 specifically conjugates the UBL ubiquitin-fold modifier 1 (UFM1) to target proteins.

Structure

The UFC1 protein is composed of 107 amino acids and has a molecular weight of approximately 12 kDa. It contains a ubiquitin-conjugating (UBC) domain, which is responsible for its enzymatic activity.

Clinical significance

Mutations in the UFC1 gene have been associated with a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In particular, overexpression of UFC1 has been observed in several types of cancer, suggesting a potential role in tumorigenesis.

See also

• Ubiquitin
• Ubiquitination
• Ubiquitin-conjugating enzyme
• Ubiquitin-fold modifier 1

External links

• UFC1 at the National Center for Biotechnology Information