Unconjugated hyperbilirubinemia

Unconjugated Hyperbilirubinemia is a medical condition characterized by high levels of unconjugated bilirubin in the bloodstream. This condition is often associated with liver diseases and blood disorders, and can lead to jaundice if left untreated.

Causes

Unconjugated hyperbilirubinemia can be caused by several factors, including hemolytic anemia, Gilbert's syndrome, and Crigler-Najjar syndrome. These conditions increase the production of bilirubin or decrease the liver's ability to convert unconjugated bilirubin into its conjugated form.

Symptoms

The primary symptom of unconjugated hyperbilirubinemia is jaundice, which is characterized by a yellowing of the skin and the whites of the eyes. Other symptoms may include fatigue, abdominal pain, and nausea.

Diagnosis

Diagnosis of unconjugated hyperbilirubinemia typically involves a blood test to measure the levels of bilirubin in the bloodstream. Additional tests may be performed to determine the underlying cause of the condition.

Treatment

Treatment for unconjugated hyperbilirubinemia depends on the underlying cause. In cases of hemolytic anemia, treatment may involve blood transfusions or medications to suppress the immune system. For Gilbert's syndrome and Crigler-Najjar syndrome, treatment may involve phototherapy or liver transplantation.

See Also

• Bilirubin
• Jaundice
• Liver diseases
• Blood disorders