Unipolar brush cell

From WikiMD's Wellness Encyclopedia

The Unipolar Brush Cell (UBC) is a type of interneuron found primarily in the granule cell layer of the cerebellum. These cells are unique in their morphology and synaptic connections, and play a crucial role in the processing of sensory information.

Morphology[edit | edit source]

UBCs are characterized by a single, brush-like dendrite from which they derive their name. This dendrite is covered in numerous small protrusions, or dendritic spines, which form synapses with incoming mossy fiber axons. The cell body of a UBC is small and round, and gives rise to a single, thin axon that projects to the molecular layer of the cerebellum.

Function[edit | edit source]

UBCs are thought to play a role in the processing of sensory information in the cerebellum. They receive input from mossy fibers, which carry sensory information from various parts of the body. The unique morphology of UBCs allows them to integrate this information and pass it on to other cells in the cerebellum.

Clinical Significance[edit | edit source]

Alterations in the number or function of UBCs have been implicated in a number of neurological disorders, including ataxia, autism, and schizophrenia. Further research is needed to fully understand the role of these cells in health and disease.

See Also[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD