Urea transporter 2

Urea transporter 2 (UT2), also known as SLC14A2, is a protein that in humans is encoded by the SLC14A2 gene. It is a member of the urea transporter family, which plays a crucial role in the kidney's ability to concentrate urine.

Function

Urea transporter 2 is a transmembrane protein that facilitates the passive transport of urea across the plasma membrane. This is particularly important in the kidney, where urea concentration is a key part of the urine concentration process. UT2 is predominantly expressed in the inner medullary collecting duct (IMCD) of the kidney, where it aids in the reabsorption of urea, contributing to the osmotic gradient necessary for water reabsorption.

Structure

The SLC14A2 gene is located on the chromosome 18 (human) and spans approximately 31 kilobases. The protein encoded by this gene, UT2, is a 55-kDa protein that is predicted to have 10 transmembrane domains. The protein structure is highly conserved among mammals, suggesting a critical physiological role.

Clinical significance

Mutations in the SLC14A2 gene can lead to a reduction in urea transport, which can result in a variety of renal disorders. For example, a decrease in urea transport can lead to urine concentration defect, a condition characterized by the inability to produce concentrated urine. This can result in excessive urine production and, in severe cases, dehydration.

See also

• Urea transporter
• SLC14A1
• Urine concentration test