Vaborbactam

From WikiMD's Wellnesspedia

Vaborbactam is a beta-lactamase inhibitor that is used in combination with meropenem, a carbapenem antibiotic, to treat certain types of bacterial infections. It is marketed under the brand name Vabomere.

Mechanism of action[edit | edit source]

Vaborbactam works by blocking the action of beta-lactamase enzymes, thereby preventing them from breaking down antibiotics such as meropenem. This allows the antibiotics to effectively kill the bacteria causing the infection.

Medical uses[edit | edit source]

Vaborbactam is used in combination with meropenem to treat complicated urinary tract infections, including pyelonephritis. It is also used to treat bacterial infections that are resistant to other antibiotics.

Side effects[edit | edit source]

Common side effects of vaborbactam include headache, diarrhea, and nausea. In rare cases, it can cause serious side effects such as allergic reactions, seizures, and Clostridium difficile-associated diarrhea.

History[edit | edit source]

Vaborbactam was approved for medical use in the United States in 2017. It was developed by The Medicines Company, and is marketed by Melinta Therapeutics.

See also[edit | edit source]


Vaborbactam Resources

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Contributors: Prab R. Tumpati, MD