Vaborbactam
Vaborbactam is a beta-lactamase inhibitor used in combination with the antibiotic meropenem to treat certain serious bacterial infections. It is particularly effective against carbapenem-resistant Enterobacteriaceae (CRE), which are a significant cause of hospital-acquired infections.
Mechanism of Action[edit | edit source]
Vaborbactam works by inhibiting the activity of beta-lactamase enzymes produced by bacteria. These enzymes typically break down beta-lactam antibiotics, rendering them ineffective. By inhibiting these enzymes, vaborbactam allows meropenem to retain its antibacterial activity against resistant strains.
Clinical Use[edit | edit source]
Vaborbactam is used in combination with meropenem for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis, and for the treatment of complicated intra-abdominal infections (cIAIs). It is also used for the treatment of hospital-acquired pneumonia and ventilator-associated pneumonia.
Pharmacokinetics[edit | edit source]
Vaborbactam is administered intravenously and has a half-life that allows for dosing every 8 hours when combined with meropenem. It is primarily excreted unchanged in the urine.
Side Effects[edit | edit source]
Common side effects of vaborbactam include headache, nausea, diarrhea, and infusion site reactions. Serious side effects may include allergic reactions and seizures.
Approval and Availability[edit | edit source]
Vaborbactam was approved by the Food and Drug Administration (FDA) in 2017 for use in combination with meropenem. It is marketed under the brand name Vabomere.
See Also[edit | edit source]
- Beta-lactamase inhibitor
- Meropenem
- Carbapenem-resistant Enterobacteriaceae
- Hospital-acquired infection
- Urinary tract infection
- Intra-abdominal infection
- Pneumonia
References[edit | edit source]
External Links[edit | edit source]
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