Meropenem/vaborbactam

Meropenem/vaborbactam is a combination antibiotic used to treat complicated urinary tract infections (cUTI), including kidney infections. It contains meropenem, a carbapenem antibiotic, and vaborbactam, a beta-lactamase inhibitor. This combination is used to treat infections caused by certain bacteria that are resistant to meropenem alone.

Mechanism of Action[edit | edit source]

Meropenem works by inhibiting the formation of the bacterial cell wall, leading to cell death. Vaborbactam protects meropenem from degradation by certain enzymes (beta-lactamases) produced by bacteria, thereby enhancing the effectiveness of meropenem.

Uses[edit | edit source]

Meropenem/vaborbactam is used to treat complicated urinary tract infections, including pyelonephritis, caused by susceptible bacteria. It is also used to treat certain types of Klebsiella pneumoniae infections.

Side Effects[edit | edit source]

Common side effects of meropenem/vaborbactam include headache, diarrhea, and infusion site reactions. Serious side effects may include allergic reactions, seizures, and Clostridium difficile-associated diarrhea.

Drug Interactions[edit | edit source]

Meropenem/vaborbactam may interact with other medications, including valproic acid and probenecid.

Dosage and Administration[edit | edit source]

Meropenem/vaborbactam is administered intravenously. The dosage and duration of treatment depend on the type and severity of the infection.

Precautions[edit | edit source]

Before using meropenem/vaborbactam, patients should inform their healthcare provider if they have a history of allergies to beta-lactam antibiotics, kidney disease, or seizures.

See Also[edit | edit source]

Meropenem/vaborbactam Resources
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