Vaccine-naive
Vaccine-naive
A person is considered vaccine-naive if they have not been previously vaccinated against a particular disease. This term is often used in the context of clinical trials and epidemiological studies to describe individuals who have not received any prior immunization for the disease being studied.
Definition[edit | edit source]
The term "vaccine-naive" refers to individuals who have not been exposed to a specific vaccine. This can apply to any vaccine-preventable disease, such as measles, mumps, rubella, influenza, or COVID-19. Being vaccine-naive means that the person's immune system has not been primed by a vaccine to recognize and fight the pathogen associated with the disease.
Clinical Trials[edit | edit source]
In clinical trials, vaccine-naive participants are often sought to evaluate the efficacy and safety of new vaccines. These individuals provide a baseline for understanding how the vaccine performs in a population that has not been previously exposed to the vaccine antigen. Trials may compare vaccine-naive individuals to those who have been previously vaccinated to assess differences in immune response and protection.
Epidemiology[edit | edit source]
From an epidemiological perspective, vaccine-naive populations can be at higher risk of contracting and spreading infectious diseases. Public health strategies often focus on increasing vaccination coverage to reduce the number of vaccine-naive individuals, thereby decreasing the potential for outbreaks.
Immunology[edit | edit source]
In immunology, the response of a vaccine-naive individual to a vaccine is of particular interest. The initial exposure to a vaccine antigen in a vaccine-naive person typically results in a primary immune response, characterized by the production of antibodies and the activation of memory cells. Subsequent exposures, either through booster vaccinations or natural infection, can lead to a more robust secondary immune response.
Public Health Implications[edit | edit source]
Addressing vaccine-naivety is a critical component of public health initiatives aimed at controlling infectious diseases. Efforts to reduce the number of vaccine-naive individuals include public education campaigns, vaccination programs, and policies that encourage or mandate vaccination.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
