Verdeso

Verdeso - a synthetic glucocorticosteroid for topical use, with anti inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid responsive genes occur. This agent induces transcription of genes coding for anti inflammatory proteins, including lipocortin 1, interleukin 10, interleukin 1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin 1 has an inhibitory effect on phospholipase a2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Verdeso for any updates.

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