Very low density lipoprotein
Very Low-Density Lipoprotein (VLDL) is a type of lipoprotein produced by the liver. It is one of the five major groups of lipoproteins, which, in order of sizes, largest to smallest, are chylomicrons, VLDL, intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). VLDL particles transport triglycerides and cholesterol that are synthesized in the liver to various tissues throughout the body.
Structure[edit | edit source]
VLDL particles are assembled in the liver from triglycerides, cholesterol, and apolipoproteins. The particles have a core of triglycerides and cholesterol surrounded by a shell of phospholipids, free cholesterol, and apolipoproteins.
Function[edit | edit source]
The primary role of VLDL particles is to transport triglycerides from the liver to adipose tissue and muscle. Once the triglycerides have been delivered, the VLDL particles are converted into intermediate-density lipoproteins (IDL), and then into low-density lipoproteins (LDL).
Clinical significance[edit | edit source]
High levels of VLDL cholesterol have been associated with the development of atherosclerosis, which can lead to diseases such as coronary artery disease and stroke. Therefore, maintaining healthy levels of VLDL cholesterol is important for cardiovascular health.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
