Vicine
A chemical compound found in certain plants
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Vicine is a naturally occurring glycoside found in certain plants, most notably in fava beans (Vicia faba). It is a pyrimidine glucoside and is chemically classified as 1,2,4-trihydroxy-5-(β-D-glucopyranosyloxy)pyrimidine. Vicine is of particular interest due to its role in favism, a condition that affects individuals with a deficiency in the enzyme glucose-6-phosphate dehydrogenase (G6PD).
Occurrence[edit | edit source]
Vicine is primarily found in the seeds of the fava bean plant. It is one of the two main glycosides present in fava beans, the other being convicine. These compounds are part of the plant's natural defense mechanism against pests and diseases.
Biological Effects[edit | edit source]
In individuals with G6PD deficiency, the ingestion of vicine can lead to the development of hemolytic anemia. This occurs because vicine is metabolized into divicine, a compound that can cause oxidative stress in red blood cells. The lack of G6PD enzyme impairs the ability of red blood cells to handle this oxidative stress, leading to their premature destruction.
Metabolism[edit | edit source]
Upon ingestion, vicine is hydrolyzed to produce divicine. Divicine is the active compound that exerts oxidative stress on red blood cells. The process of hydrolysis and subsequent oxidative stress is what leads to the symptoms of favism in susceptible individuals.
Health Implications[edit | edit source]
The consumption of fava beans or other sources of vicine is generally safe for most people. However, individuals with G6PD deficiency should avoid these foods to prevent hemolytic episodes. G6PD deficiency is a genetic condition that is more prevalent in certain populations, including those of Mediterranean, African, and Asian descent.
Also see[edit | edit source]
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