Volpristin

Volpristin is a type of antibiotic that belongs to the class of streptogramin antibiotics. It is used in combination with another streptogramin antibiotic, quinupristin, to form a drug known as quinupristin/dalfopristin. This combination is used to treat certain types of bacterial infections that are resistant to other antibiotics.

Mechanism of Action

Volpristin works by inhibiting the protein synthesis of bacteria. It binds to the 50S subunit of the bacterial ribosome, preventing the elongation of the peptide chain. This inhibits the growth of the bacteria and eventually leads to their death.

Uses

Volpristin is used in combination with quinupristin to treat infections caused by Staphylococcus aureus and Enterococcus faecium that are resistant to other antibiotics. This includes infections of the skin, lungs, and blood.

Side Effects

Common side effects of volpristin include nausea, vomiting, and diarrhea. More serious side effects can include allergic reactions, liver damage, and blood clots.

Contraindications

Volpristin should not be used in people who are allergic to it or to any other streptogramin antibiotics. It should also be used with caution in people with liver disease.

See Also

• Antibiotic resistance
• Protein synthesis inhibitor
• Streptogramin