Quinupristin

Quinupristin is a type of antibiotic that is used in combination with dalfopristin to treat certain types of bacterial infections. This combination is often referred to as Synercid. Quinupristin and dalfopristin are both streptogramin antibiotics, which work by inhibiting the growth of bacteria.

Mechanism of action[edit | edit source]

Quinupristin works by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis. This action is synergistic with that of dalfopristin, which binds at a nearby site on the same ribosomal subunit, causing a conformational change that enhances the binding of quinupristin.

Uses[edit | edit source]

Quinupristin/dalfopristin is used to treat serious or life-threatening infections caused by susceptible strains of Staphylococcus aureus (including methicillin-resistant strains), Streptococcus pyogenes, Streptococcus agalactiae, and certain Enterococcus species (including E. faecium).

Side effects[edit | edit source]

Common side effects of quinupristin/dalfopristin include pain and inflammation at the injection site, nausea, vomiting, rash, and diarrhea. Less common side effects include changes in liver function tests, allergic reactions, and changes in blood counts.

See also[edit | edit source]

Quinupristin Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.