Dalfopristin

Dalfopristin is a streptogramin antibiotic. It is used in combination with quinupristin to form a drug known as Synercid. Dalfopristin inhibits the early phase of protein synthesis in the bacterium's cycle, thereby making it more susceptible to the action of quinupristin.

Mechanism of action

Dalfopristin binds to the 50S subunit of the bacterial ribosome, thereby inhibiting the early phase of protein synthesis. This makes the bacterium more susceptible to the action of quinupristin, which inhibits the late phase of protein synthesis.

Uses

Dalfopristin is used in combination with quinupristin to form a drug known as Synercid. This combination is used to treat infections caused by Enterococcus faecium bacteria that are resistant to other antibiotics.

Side effects

Common side effects of dalfopristin include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause serious side effects such as allergic reactions, liver damage, and blood clots.

Interactions

Dalfopristin can interact with other medications, including warfarin, cyclosporine, and certain statins. It can also interact with grapefruit juice, which can increase the levels of dalfopristin in the body and increase the risk of side effects.

See also

• Quinupristin
• Streptogramin antibiotic
• Protein synthesis

Dalfopristin Resources
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