Sulfadiazine

Information about Sulfadiazine[edit source]

Sulfadiazine is a sulfonamide antibacterial agent used in the therapy of mild-to-moderate infections due to sensitive organisms.

Sulfadiazine structure

[File:Sulfadiazine-3D-vdW.png|Sulfadiazine 3 D|thumb]]

Liver safety of Sulfadiazine[edit source]

Sulfadiazine, like other sulfonamides, is a well known cause of clinically apparent, idiosyncratic liver injury.

Mechanism of action of Sulfadiazine[edit source]

Sulfadiazine (sul" fa dye' a zeen) is an orally administered sulfonamide antibiotic that acts by inhibition of folic acid synthesis, which is required for bacterial replication and growth.

FDA approval information for Sulfadiazine[edit source]

Different forms of sulfonamides have been used in clinical medicine since the 1930s. Sulfadiazine was approved for use in the United States in 1973. Current indications are many and include urinary tract infections and otitis media due to sensitive organisms.

Clinical use of Sulfadiazine[edit source]

Sulfadiazine is also used as prophylaxis against rheumatic fever and meningococcal meningitis. It is used in combination with pyrimethamine for prevention and treatment of toxoplasmosis and is also effective in nocardiasis, chancroid, and trachoma. It is used as adjunctive therapy for chloroquine-resistant malaria and several forms of bacterial meningitis.

Dosage and administration for Sulfadiazine[edit source]

Sulfadiazine is available in multiple generic forms in tablets of 500 mg. For urinary tract infections, the usual dose is 2 to 4 grams daily in 3 to 6 divided doses. Common side effects are diarrhea, nausea, gastrointestinal upset, rash and fever.

The following are sulfonamide drugs

Sulfadiazine Resources
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