Artesunate/amodiaquine

From WikiMD's Wellness Encyclopedia

Artesunate/amodiaquine is a combination medication used in the treatment of malaria, specifically for uncomplicated Plasmodium falciparum malaria. This medication combines two active ingredients, artesunate and amodiaquine, both of which are antimalarial drugs.

Chemical structure of artesunate/amodiaquine

Mechanism of Action[edit | edit source]

Artesunate is a sesquiterpene lactone derivative, which quickly reduces the number of parasites in the first three days of infection, while amodiaquine, a 4-aminoquinoline, clears remaining parasites.

Usage and Administration[edit | edit source]

Artesunate/amodiaquine is administered orally. The dosage and duration of treatment depend on the patient's age and the severity of the disease. It is typically given once daily for three days.

Side Effects[edit | edit source]

Common side effects include abdominal pain, vomiting, and diarrhea. Serious side effects may include a slow heart rate, hearing problems, and low blood cell levels. It is not recommended in people with a history of liver or kidney disease.

Resistance[edit | edit source]

Resistance to artesunate/amodiaquine has been reported, particularly in Southeast Asia and South America. This resistance is typically due to genetic changes in the malaria parasite.

History[edit | edit source]

Artesunate/amodiaquine was first developed in the 1980s as a response to increasing resistance to chloroquine. It is on the World Health Organization's List of Essential Medicines.

See Also[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Kondreddy Naveen