Sesquiterpene lactone

From WikiMD's Wellness Encyclopedia

Sesquiterpene lactones are a class of organic compounds that are a subclass of terpenes. They are known for their various bioactive properties, which include anti-inflammatory, antitumor, antiviral, and antibacterial activities.

Structure[edit | edit source]

Sesquiterpene lactones are characterized by a three-ring structure, which includes a lactone ring. The lactone ring is a cyclic ester that can be found in a variety of different forms, depending on the specific sesquiterpene lactone.

Biosynthesis[edit | edit source]

The biosynthesis of sesquiterpene lactones is a complex process that involves the mevalonate pathway. This pathway is responsible for the production of all terpenes and terpenoids, including sesquiterpene lactones.

Biological activity[edit | edit source]

Sesquiterpene lactones have a wide range of biological activities. They are known for their anti-inflammatory properties, which can be attributed to their ability to inhibit the NF-κB pathway. They also have antitumor properties, which are believed to be due to their ability to induce apoptosis in cancer cells. In addition, they have antiviral and antibacterial activities.

Occurrence[edit | edit source]

Sesquiterpene lactones are found in a variety of plants, particularly in the Asteraceae family. They are also found in the Magnoliaceae and Ranunculaceae families.

See also[edit | edit source]

Sesquiterpene lactone Resources
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Contributors: Prab R. Tumpati, MD