Netilmicin

Netilmicin is an aminoglycoside antibiotic used primarily in the treatment of infections caused by Gram-negative bacteria. It was first discovered in the 1970s and is derived from the bacterium Micromonospora inyoensis.

Pharmacology

Netilmicin works by binding to the 30S ribosomal subunit of the bacterial cell, inhibiting protein synthesis and leading to cell death. It is bactericidal in nature.

Medical Uses

Netilmicin is used to treat serious infections caused by susceptible strains of Gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. It is often used in combination with a beta-lactam antibiotic for a synergistic effect.

Side Effects

Like other aminoglycosides, netilmicin can cause ototoxicity and nephrotoxicity. Monitoring of blood levels is often necessary during treatment to prevent these side effects.

Resistance

Resistance to netilmicin can occur through several mechanisms, including modification by aminoglycoside modifying enzymes, alteration of the target site, or reduced uptake into the bacterial cell.

See Also

• Aminoglycoside
• Antibiotic resistance
• Gram-negative bacteria

References

• Need help finding a doctor or specialist anywhere in the world? WikiMD's DocFinder can help with millions of doctors!

This article is a stub. Help WikiMD grow by registering to expand it. Editing is available only to registered and verified users. About WikiMD: A comprehensive, free health & wellness encyclopedia.

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian