Penicillin g benzathine

What is Penicillin g benzathine?

• Penicillin g benzathine (Bicillin LA) is an antibiotic medication used useful for the treatment of a number of bacterial infections.
• It is used to treat strep throat, diphtheria, syphilis, and yaws.
• It is also used to prevent rheumatic fever.

Benzathine benzylpenicillin 2

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Benzylpenicillin-Benzathin Structural Formula V.1

What are the uses of this medicine?

Penicillin g benzathine (Bicillin L-A) is used for the treatment of:

• Mild-to-moderate infections of the upper-respiratory tract due to susceptible streptococci.
• Venereal infections—Syphilis, yaws, bejel, and pinta.

Medical Conditions in which Penicillin G Benzathine Therapy is indicated as Prophylaxis:

• Rheumatic fever and/or chorea—Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions.
• It has also been used as follow-up prophylactic therapy for rheumatic heart disease and acute glomerulonephritis.

How does this medicine work?

• Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication.
• It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable.
• Penicillin G benzathine has an extremely low solubility and, thus, the drug is slowly released from intramuscular injection sites. The drug is hydrolyzed to penicillin G.
• This combination of hydrolysis and slow absorption results in blood serum levels much lower but much more prolonged than other parenteral penicillins.

Who Should Not Use this medicine ?

This medicine cannot be used in patients with:

• A history of a previous hypersensitivity reaction to any of the penicillins.

What drug interactions can this medicine cause?

• Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Be sure to mention any of the following:

• probenecid (Probalan) and tetracycline (Achromycin)

Is this medicine FDA approved?

• Benzathine benzylpenicillin was patented in 1950.

How should this medicine be used?

Recommended dosage: Streptococcal (Group A) Upper Respiratory Infections (for example, pharyngitis):

• Adults—a single injection of 1,200,000 units
• older pediatric patients—a single injection of 900,000 units
• Infants and pediatric patients under 60 lbs.—300,000 to 600,000 units.

Syphilis:

• Primary, secondary, and latent—2,400,000 units (1 dose).
• Late (tertiary and neurosyphilis)—2,400,000 units at 7-day intervals for three doses.
• Congenital—under 2 years of age: 50,000 units/kg/body weight
• Ages 2 to 12 years: adjust dosage based on adult dosage schedule.

Yaws, Bejel, and Pinta—1,200,000 units (1 injection)

Prophylaxis—for rheumatic fever and glomerulonephritis

• Following an acute attack, penicillin G benzathine (parenteral) may be given in doses of 1,200,000 units once a month or 600,000 units every 2 weeks.

Administration:

• Penicillin G benzathine injection comes as a suspension (liquid) in a prefilled syringe to inject into the muscles of the buttocks or thigh by a doctor or nurse in a medical facility.
• Penicillin G benzathine injection may be given as a single dose.
• When used to treat or prevent certain serious infections, additional doses may be given at least 7 days apart.
• If you stop using penicillin G benzathine injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As injection comes as a suspension (liquid) in a prefilled syringe.

This medicine is available in fallowing brand namesː

• Bicillin LA

What side effects can this medication cause?

The most common side effects of this medicine include:

• Hypersensitivity reactions
• Nausea
• vomiting
• blood in stool
• Nervousness
• tremors
• dizziness
• somnolence
• confusion
• anxiety
• Hypoxia
• apnea
• dyspnea
• Diaphoresis
• Blurred vision
• blindness
• Neurogenic bladder
• hematuria
• proteinuria
• impotence
• priapism
• Joint disorder
• periostitis
• exacerbation of arthritis
• myoglobinuria
• rhabdomyolysis
• Injection site reactions including pain
• inflammation
• lump
• abscess
• necrosis
• edema
• hemorrhage
• cellulitis
• atrophy
• ecchymosis
• skin ulcer
• Lymphadenopathy

What special precautions should I follow?

• Penicillin G benzathine injection should never be given intravenously (into a vein) because this may cause serious or life-threatening side effects or death.
• Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) have been reported in patients taking penicillin G.
• Clostridioides difficile associated-diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Bicillin L-A. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.
• Do not inject into or near an artery or nerve. Injection into or near a nerve may result in permanent neurological damage. FOR DEEP INTRAMUSCULAR INJECTION ONLY.
• Prescribing Bicillin L-A in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of a development of drug-resistant bacteria.
• Penicillin should be used with caution in individuals with histories of significant allergies and/or asthma.
• Prolonged use of antibiotics may promote the overgrowth of nonsusceptible organisms, including fungi. Should superinfection occur, appropriate measures should be taken.
• Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.
• Patients should be counseled that antibacterial drugs including Bicillin L-A should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold).
• Bicillin L-A is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
• Caution should be exercised when penicillin G benzathine is administered to a nursing woman.

What to do in case of emergency/overdose?

Symptoms of overdosage may include:

• neuromuscular hyperirritability
• convulsive seizures

Management of overdosage:

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• There are, however, no adequate and well-controlled studies in pregnant women showing conclusively that harmful effects of these drugs on the fetus can be excluded.

Can this medicine be used in children?

• The safety and effectiveness of Penicillin G benzathine in pediatric patients have been established.

What are the active and inactive ingredients in this medicine?

Active ingredient:

• PENICILLIN G BENZATHINE

Inactive ingredients (intravenous):

• LECITHIN, SOYBEAN
• CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED
• POVIDONE, UNSPECIFIED
• METHYLPARABEN
• PROPYLPARABEN
• SODIUM CITRATE, UNSPECIFIED FORM
• WATER

Who manufactures and distributes this medicine?

Distributed by

• Pfizer Inc
• New York, NY

What should I know about storage and disposal of this medication?

• Store in a refrigerator, 2° to 8°C (36° to 46°F).
• Keep from freezing.

• Dailymed label info on Penicillin g benzathine
• FDA Penicillin g benzathine

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