Cefetamet

Cefetamet is a third-generation cephalosporin antibiotic used in the treatment of bacterial infections. It is effective against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable option in the arsenal against bacterial infections. Cefetamet's mechanism of action involves inhibiting bacterial cell wall synthesis, leading to the death of the bacteria. This antibiotic is particularly useful for treating respiratory tract infections, urinary tract infections, and skin infections.

Medical Uses

Cefetamet is indicated for the treatment of various bacterial infections, including:

• Acute bacterial exacerbations of chronic bronchitis
• Uncomplicated urinary tract infections (UTIs)
• Otitis media (middle ear infections)
• Pharyngitis and tonsillitis
• Sinusitis
• Skin and skin structure infections

It is important to note that the use of cefetamet should be guided by susceptibility patterns of the local bacterial populations and specific patient needs.

Pharmacology

Mechanism of Action

Cefetamet inhibits the synthesis of the bacterial cell wall by binding to penicillin-binding proteins (PBPs), which are essential for cell wall integrity. This action ultimately leads to bacterial cell lysis and death.

Pharmacokinetics

Cefetamet is well absorbed from the gastrointestinal tract, with its bioavailability being significantly enhanced when taken with food. It is metabolized minimally and excreted primarily through the kidneys. Therefore, dose adjustments may be necessary in patients with renal impairment.

Adverse Effects

The adverse effects of cefetamet are similar to those of other cephalosporins and may include:

• Diarrhea
• Nausea and vomiting
• Rash
• Eosinophilia
• Transaminase elevations

Serious adverse effects are rare but can include anaphylaxis, Clostridium difficile-associated diarrhea, and Stevens-Johnson syndrome.

Drug Interactions

Cefetamet may interact with other medications, such as:

• Probenecid, which can increase the concentration of cefetamet by decreasing its renal excretion
• Anticoagulants (e.g., warfarin), as cefetamet can potentiate the anticoagulant effect

Patients should inform their healthcare provider of all medications they are taking to avoid potential drug interactions.

Contraindications

Cefetamet is contraindicated in patients with a known allergy to cephalosporin antibiotics. Caution is advised in patients with a history of penicillin allergy, as cross-reactivity may occur.

See Also

• Antibiotics
• Cephalosporin
• Bacterial infection