Aztreonam

Aztreonam structure

Information about Aztreonam[edit source]

Aztreonam is a parenterally administered, synthetic monobactam antibiotic that is specifically active against aerobic gram-negative bacilli is resistant to many beta-lactamases. Aztreonam therapy is often accompanied by mild, asymptomatic elevations in serum aminotransferase levels, but it has not been reported to cause clinically apparent liver injury.

Mechanism of action of Aztreonam[edit source]

Aztreonam (az tree' oh nam) is a monocyclic beta-lactam compound (monobactam) that was originally isolated from Chromobacterium violaceum. It acts by binding to penicillin binding proteins inhibiting cell wall synthesis and decreasing bacterial growth. Aztreonam is active mostly against gram negative organisms and more closely resembles aminoglycosides rather than penicillins.

Aztreonam ball and spoke

FDA approval information for Aztreonam[edit source]

Aztreonam was approved for use in the United States in 1986 and is indicated in the treatment of various moderate-to-severe systemic or skin, intra-abdominal, genitourinary, and respiratory gram-negative infections. Aztreonam is available in generic forms and under the brand name Azactam as a powder or a solution for injection, and under the brand name Cayston as a powder for solution to use in inhalational therapy.

Dosage and administration for Aztreonam[edit source]

The recommended dosage is 0.5 to 2 g by intravenous or intramuscular injection every 8 to 12 hours, typically for 5 to 14 days.

Side effects of Aztreonam[edit source]

The most common side effects of aztreonam are injection site phlebitis, rash and gastrointestinal symptoms.

Antibacterial agents[edit source]

antibacterial agents, classes
- aminoglycosides, carbapenems, cephalosporins, fluoroquinolones, glycopeptides, macrolide antibiotics, penicillins, sulfonamides,

- tetracyclines
  - antibacterial agents, miscellaneous
- aztreonam, chloramphenicol, clindamycin, daptomycin, fosfomycin, linezolid, metronidazole, nitrofurantoin, quinupristin-dalfopristin, tedizolid, tinidazole, vancomycin

antitoxins

bezlotoxumab, obiltoxaximab, raxibacumab
antituberculosis agents
antiviral agents
leishmaniasis agents
miltefosine

leprosy agents

clofazimine, dapsone, rifampin

Aztreonam Resources
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