Ceftiolene

Ceftiolene

Ceftolozane is an antibiotic used in the treatment of certain bacterial infections. It is a cephalosporin antibiotic, a class of drugs that work by inhibiting the synthesis of bacterial cell walls, leading to cell death. Ceftolozane is often used in combination with tazobactam, a beta-lactamase inhibitor, to increase its effectiveness against resistant strains of bacteria.

Mechanism of Action

Ceftolozane works by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the final step of peptidoglycan synthesis in bacterial cell walls, leading to cell lysis and death.

Clinical Use

Ceftolozane is used in the treatment of complicated urinary tract infections (cUTIs) and complicated intra-abdominal infections (cIAIs). It is also used for the treatment of pneumonia acquired in hospitals or ventilator-associated pneumonia.

Resistance

Resistance to ceftolozane can occur through several mechanisms, including the production of beta-lactamase enzymes that can inactivate the drug, alterations in the target PBPs, and changes in bacterial cell wall permeability.

Side Effects

Common side effects of ceftolozane include nausea, diarrhea, and headache. Serious side effects can include allergic reactions, Clostridium difficile-associated diarrhea, and seizures.

See Also

• Cephalosporin
• Antibiotic resistance
• Penicillin-binding protein
• Beta-lactamase

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