Ceftiolene
Ceftolozane is an antibiotic used in the treatment of certain bacterial infections. It is a cephalosporin antibiotic, a class of drugs that work by inhibiting the synthesis of bacterial cell walls, leading to cell death. Ceftolozane is often used in combination with tazobactam, a beta-lactamase inhibitor, to increase its effectiveness against resistant strains of bacteria.
Mechanism of Action[edit]
Ceftolozane works by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the final step of peptidoglycan synthesis in bacterial cell walls, leading to cell lysis and death.
Clinical Use[edit]
Ceftolozane is used in the treatment of complicated urinary tract infections (cUTIs) and complicated intra-abdominal infections (cIAIs). It is also used for the treatment of pneumonia acquired in hospitals or ventilator-associated pneumonia.
Resistance[edit]
Resistance to ceftolozane can occur through several mechanisms, including the production of beta-lactamase enzymes that can inactivate the drug, alterations in the target PBPs, and changes in bacterial cell wall permeability.
Side Effects[edit]
Common side effects of ceftolozane include nausea, diarrhea, and headache. Serious side effects can include allergic reactions, Clostridium difficile-associated diarrhea, and seizures.
See Also[edit]
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