Sulfamethoxypyridazine

Sulfamethoxypyridazine

Chemical structure of Sulfamethoxypyridazine

Sulfamethoxypyridazine is a sulfonamide antibiotic used in the treatment of various bacterial infections. It is a member of the sulfonamide class of drugs, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfamethoxypyridazine is known for its broad-spectrum activity against a variety of Gram-positive and Gram-negative bacteria.

Mechanism of Action

Sulfamethoxypyridazine works by inhibiting the bacterial enzyme dihydropteroate synthase, which is involved in the synthesis of folic acid. Folic acid is essential for bacterial growth and replication, as it is a precursor for the synthesis of nucleic acids. By blocking this enzyme, sulfamethoxypyridazine effectively halts bacterial growth, making it a bacteriostatic agent.

Clinical Uses

Sulfamethoxypyridazine is used to treat a variety of infections, including:

• Urinary tract infections
• Respiratory tract infections
• Gastrointestinal infections
• Skin and soft tissue infections

It is often used in combination with other antibiotics to enhance its efficacy and reduce the risk of resistance development.

Pharmacokinetics

Sulfamethoxypyridazine is well absorbed from the gastrointestinal tract when administered orally. It is distributed throughout the body and can cross the blood-brain barrier. The drug is metabolized in the liver and excreted primarily through the kidneys. Its half-life allows for convenient dosing schedules, often requiring administration only once or twice daily.

Side Effects

Common side effects of sulfamethoxypyridazine include:

• Nausea
• Vomiting
• Diarrhea
• Rash

Serious side effects, although rare, can include:

• Stevens-Johnson syndrome
• Agranulocytosis
• Hepatotoxicity

Patients with a known allergy to sulfonamides should avoid using this medication.

Related Pages

• Sulfonamide (medicine)
• Antibiotic
• Bacterial resistance