Pazufloxacin

Pazufloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria. Pazufloxacin is often used in the treatment of urinary tract infections, respiratory tract infections, and skin and soft tissue infections.

Mechanism of Action

Pazufloxacin works by inhibiting the DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This inhibition prevents the bacteria from reproducing and eventually leads to their death.

Pharmacokinetics

After oral administration, Pazufloxacin is rapidly absorbed from the gastrointestinal tract. It is widely distributed throughout the body, including tissues and body fluids. The drug is primarily excreted in the urine as unchanged drug.

Side Effects

Like all medications, Pazufloxacin can cause side effects. Common side effects include nausea, diarrhea, and abdominal pain. Less common but more serious side effects can include allergic reactions, liver damage, and neuropathy.

Precautions

Patients with a history of hypersensitivity to quinolone antibiotics should avoid using Pazufloxacin. It should also be used with caution in patients with a history of seizures or other central nervous system disorders due to the risk of seizure induction.

Interactions

Pazufloxacin can interact with other medications, including antacids, iron supplements, and multivitamins containing zinc or iron. These can reduce the absorption of Pazufloxacin, reducing its effectiveness.

See Also

• Fluoroquinolone
• Antibiotic
• DNA gyrase
• Topoisomerase IV