Pazufloxacin
An article about the antibiotic Pazufloxacin
Pazufloxacin | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Pazufloxacin is a fluoroquinolone antibiotic used in the treatment of various bacterial infections. It is particularly effective against Gram-negative bacteria and is often used in clinical settings for its broad-spectrum activity.
Mechanism of Action[edit | edit source]
Pazufloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. This inhibition leads to the disruption of bacterial DNA synthesis, ultimately resulting in bacterial cell death.
Pharmacokinetics[edit | edit source]
Pazufloxacin is administered intravenously, allowing for rapid distribution throughout the body. It is known for its high tissue penetration, making it effective in treating infections in various body sites. The drug is primarily excreted through the renal system, and its half-life allows for convenient dosing schedules.
Clinical Uses[edit | edit source]
Pazufloxacin is used to treat a variety of infections, including:
- Urinary tract infections
- Respiratory tract infections
- Intra-abdominal infections
- Skin and soft tissue infections
Side Effects[edit | edit source]
Common side effects of pazufloxacin include nausea, vomiting, and diarrhea. More serious side effects can include tendonitis and tendon rupture, particularly in older patients or those on concurrent corticosteroid therapy.
Contraindications[edit | edit source]
Pazufloxacin should not be used in patients with a known hypersensitivity to quinolones. Caution is advised in patients with a history of seizures or central nervous system disorders.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD