Pazufloxacin

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An article about the antibiotic Pazufloxacin


Pazufloxacin
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Pazufloxacin is a fluoroquinolone antibiotic used in the treatment of various bacterial infections. It is particularly effective against Gram-negative bacteria and is often used in clinical settings for its broad-spectrum activity.

Mechanism of Action[edit | edit source]

Pazufloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. This inhibition leads to the disruption of bacterial DNA synthesis, ultimately resulting in bacterial cell death.

Pharmacokinetics[edit | edit source]

Pazufloxacin is administered intravenously, allowing for rapid distribution throughout the body. It is known for its high tissue penetration, making it effective in treating infections in various body sites. The drug is primarily excreted through the renal system, and its half-life allows for convenient dosing schedules.

Clinical Uses[edit | edit source]

Pazufloxacin is used to treat a variety of infections, including:

Side Effects[edit | edit source]

Common side effects of pazufloxacin include nausea, vomiting, and diarrhea. More serious side effects can include tendonitis and tendon rupture, particularly in older patients or those on concurrent corticosteroid therapy.

Contraindications[edit | edit source]

Pazufloxacin should not be used in patients with a known hypersensitivity to quinolones. Caution is advised in patients with a history of seizures or central nervous system disorders.

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