Kanamycin
Kanamycin is an aminoglycoside antibiotic introduced in 1957. It is produced by the bacterium Streptomyces kanamyceticus. Kanamycin is used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria.
Mechanism of action[edit | edit source]
Kanamycin works by binding to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis and generating errors in the transcription process. This causes the death of the bacterial cells.
Medical uses[edit | edit source]
Kanamycin is used to treat a wide variety of bacterial infections such as tuberculosis, sepsis, and urinary tract infections. It is also used in combination with other antibiotics for the treatment of multidrug-resistant tuberculosis.
Side effects[edit | edit source]
Common side effects of kanamycin include nausea, vomiting, and diarrhea. Serious side effects may include kidney problems, hearing loss, and allergic reactions.
Resistance[edit | edit source]
Bacterial resistance to kanamycin is common and is mediated through several mechanisms, including modification of the antibiotic, modification of the target sites, and efflux of the antibiotic.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
