Marbofloxacin

Marbofloxacin is a synthetic, broad-spectrum antibiotic from the fluoroquinolone drug class. It is primarily used in veterinary medicine to treat bacterial infections in animals. Marbofloxacin was first approved for use in the European Union in 1995.

Pharmacology

Marbofloxacin works by inhibiting the DNA gyrase and topoisomerase IV, two enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to the death of the bacterial cells and the resolution of the infection.

Uses

Marbofloxacin is used to treat a variety of bacterial infections in animals, including skin infections, respiratory tract infections, and urinary tract infections. It is also used to treat infections caused by Pseudomonas aeruginosa, Escherichia coli, and other susceptible bacteria.

Side Effects

As with all fluoroquinolones, side effects can occur with the use of marbofloxacin. These may include digestive upset, such as vomiting and diarrhea, and neurological side effects, such as seizures. In rare cases, it can cause damage to the cartilage in growing animals.

Precautions

Marbofloxacin should not be used in animals with a known hypersensitivity or allergy to the drug. It should also be used with caution in animals with severe kidney or liver disease. Due to the potential for cartilage damage, it should not be used in growing animals unless the benefits of treatment outweigh the risks.

See Also

• Fluoroquinolone
• Veterinary medicine
• Antibiotic resistance

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