Difloxacin

Difloxacin is a fluoroquinolone antibiotic used in veterinary medicine to treat bacterial infections. It is a broad-spectrum antibiotic that is effective against both Gram-positive and Gram-negative bacteria.

Mechanism of Action

Difloxacin works by inhibiting the DNA gyrase and topoisomerase IV, two enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This inhibition results in the death of the bacteria.

Uses

Difloxacin is primarily used in the treatment of bacterial infections in animals. It is particularly effective against Staphylococcus, Streptococcus, E. coli, and Salmonella species. It is commonly used in the treatment of skin, respiratory, and urinary tract infections in animals.

Side Effects

Like other fluoroquinolones, Difloxacin can cause side effects in some animals. These can include vomiting, diarrhea, loss of appetite, and lethargy. In rare cases, it can cause seizures or other neurological side effects.

Resistance

Bacterial resistance to Difloxacin can occur, particularly if the antibiotic is used improperly or overused. Resistance occurs when bacteria mutate in a way that makes them immune to the effects of the antibiotic.

See Also

• Fluoroquinolone
• Antibiotic resistance
• Veterinary medicine