Pristinamycin IA
Pristinamycin IA is a macrolide antibiotic that is part of the pristinamycin complex. It is produced by the bacterium Streptomyces pristinaespiralis. Pristinamycin IA is used in the treatment of various bacterial infections, particularly those caused by Gram-positive bacteria.
Chemical Structure[edit | edit source]
Pristinamycin IA is a macrolide antibiotic, which means it has a large macrocyclic lactone ring in its structure. The lactone ring of pristinamycin IA is a 16-membered ring, which is larger than the 14-membered ring found in many other macrolide antibiotics such as erythromycin. The large ring size gives pristinamycin IA unique properties compared to other macrolides.
Mechanism of Action[edit | edit source]
Pristinamycin IA works by inhibiting protein synthesis in bacteria. It binds to the 50S ribosomal subunit, preventing the formation of a functional 70S initiation complex. This inhibits the elongation phase of protein synthesis, leading to the death of the bacterial cell.
Clinical Use[edit | edit source]
Pristinamycin IA is used to treat a variety of bacterial infections, particularly those caused by Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae. It is also effective against certain Gram-negative bacteria and anaerobic bacteria. Pristinamycin IA is often used in combination with other antibiotics to increase its effectiveness.
Resistance[edit | edit source]
Resistance to pristinamycin IA can occur through several mechanisms. Some bacteria produce enzymes that modify the antibiotic, rendering it ineffective. Others alter the target site of the antibiotic, preventing it from binding to the 50S ribosomal subunit. Resistance can also occur through efflux pumps, which remove the antibiotic from the bacterial cell.
Side Effects[edit | edit source]
Like all antibiotics, pristinamycin IA can cause side effects. These can include nausea, vomiting, diarrhea, and allergic reactions. In rare cases, it can cause more serious side effects such as liver damage or hearing loss.
See Also[edit | edit source]
| This article is a stub. You can help WikiMD by registering to expand it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
