Cethromycin
An encyclopedia article about the antibiotic Cethromycin
Cethromycin[edit | edit source]
Cethromycin is a ketolide antibiotic that is used to treat various bacterial infections. It is a semi-synthetic derivative of the macrolide antibiotic erythromycin. Cethromycin is known for its effectiveness against respiratory tract infections and has been studied for its potential use in treating community-acquired pneumonia.
Mechanism of Action[edit | edit source]
Cethromycin works by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thereby preventing the translocation of peptides. This action is similar to that of other macrolides, but cethromycin has a higher affinity for the ribosomal binding site, which contributes to its effectiveness against resistant strains of bacteria.
Pharmacokinetics[edit | edit source]
Cethromycin is administered orally and is well absorbed from the gastrointestinal tract. It has a long half-life, which allows for once-daily dosing. The drug is metabolized in the liver and excreted primarily in the feces. Its pharmacokinetic profile makes it a convenient option for patients who require antibiotic therapy.
Clinical Uses[edit | edit source]
Cethromycin has been investigated for the treatment of several types of infections, including:
Its broad spectrum of activity against Gram-positive bacteria and some Gram-negative bacteria makes it a versatile option in the treatment of respiratory infections.
Side Effects[edit | edit source]
Common side effects of cethromycin include:
- Gastrointestinal disturbances such as nausea and diarrhea
- Headache
- Dizziness
These side effects are generally mild and resolve after discontinuation of the drug.
Development and Approval[edit | edit source]
Cethromycin was developed as a response to the growing issue of antibiotic resistance. It was designed to overcome the limitations of earlier macrolides, such as erythromycin, by providing a broader spectrum of activity and improved pharmacokinetic properties. However, as of the latest updates, cethromycin has not been approved by the Food and Drug Administration (FDA) for use in the United States.
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