Sitafloxacin

Sitafloxacin is a fluoroquinolone antibiotic used in the treatment of various bacterial infections. It is particularly effective against gram-positive bacteria and gram-negative bacteria, including those resistant to other fluoroquinolones.

Mechanism of Action[edit | edit source]

Sitafloxacin works by inhibiting the DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This inhibition results in the death of the bacteria, effectively treating the infection.

Medical Uses[edit | edit source]

Sitafloxacin is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and intra-abdominal infections. It is also used in the treatment of tuberculosis, particularly multi-drug resistant strains.

Side Effects[edit | edit source]

Common side effects of sitafloxacin include nausea, diarrhea, headache, and dizziness. More serious side effects can include tendon rupture, QT prolongation, and hypersensitivity reactions.

Drug Interactions[edit | edit source]

Sitafloxacin can interact with other medications, including antacids, iron supplements, and multivitamins. These interactions can decrease the absorption of sitafloxacin, reducing its effectiveness.

Precautions[edit | edit source]

Patients with a history of tendonitis or tendon rupture should use sitafloxacin with caution, as it can increase the risk of these conditions. Additionally, sitafloxacin should be used with caution in patients with a history of QT prolongation or other heart conditions.

See Also[edit | edit source]

Need help finding a doctor or specialist anywhere in the world? WikiMD's DocFinder can help with millions of doctors!

This article is a stub. Help WikiMD grow by registering to expand it. Editing is available only to registered and verified users. About WikiMD: A comprehensive, free health & wellness encyclopedia.