Tosufloxacin
Tosufloxacin[edit | edit source]
Tosufloxacin is a fluoroquinolone antibiotic used in the treatment of various bacterial infections. It is particularly effective against Gram-positive bacteria and some Gram-negative bacteria. Tosufloxacin is known for its broad-spectrum antibacterial activity and is used in clinical settings to treat infections such as respiratory tract infections, urinary tract infections, and skin infections.
Mechanism of Action[edit | edit source]
Tosufloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes that are crucial for bacterial DNA replication and transcription. By interfering with these enzymes, tosufloxacin prevents the bacteria from multiplying and repairing their DNA, leading to bacterial cell death.
Pharmacokinetics[edit | edit source]
Tosufloxacin is well absorbed from the gastrointestinal tract when administered orally. It has a high bioavailability and is widely distributed throughout the body, including in tissues and fluids. The drug is metabolized in the liver and excreted primarily through the kidneys.
Clinical Uses[edit | edit source]
Tosufloxacin is used to treat a variety of infections, including:
- Community-acquired pneumonia
- Acute bronchitis
- Sinusitis
- Urinary tract infections
- Skin and soft tissue infections
Side Effects[edit | edit source]
Common side effects of tosufloxacin include nausea, vomiting, diarrhea, and headache. Like other fluoroquinolones, it may also cause more serious side effects such as tendonitis and tendon rupture, particularly in older adults and those on concurrent corticosteroid therapy.
Contraindications[edit | edit source]
Tosufloxacin should not be used in patients with a known hypersensitivity to fluoroquinolones. Caution is advised in patients with a history of seizures or central nervous system disorders.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD