Dihydrostreptomycin
An antibiotic used in the treatment of tuberculosis and other bacterial infections
Dihydrostreptomycin[edit | edit source]
Dihydrostreptomycin is an aminoglycoside antibiotic derived from streptomycin. It is primarily used in the treatment of tuberculosis and other bacterial infections. Dihydrostreptomycin works by inhibiting protein synthesis in bacteria, leading to cell death.
Mechanism of Action[edit | edit source]
Dihydrostreptomycin binds to the 30S subunit of the bacterial ribosome, interfering with the initiation complex and causing misreading of mRNA. This action inhibits protein synthesis, which is essential for bacterial growth and replication. The bactericidal effect of dihydrostreptomycin is concentration-dependent.
Clinical Uses[edit | edit source]
Dihydrostreptomycin is used in combination with other antibiotics to treat Mycobacterium tuberculosis infections. It is also effective against a variety of Gram-negative bacteria, including some strains of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Side Effects[edit | edit source]
The use of dihydrostreptomycin can lead to several side effects, the most significant being ototoxicity and nephrotoxicity. Ototoxicity can result in irreversible hearing loss, while nephrotoxicity can cause kidney damage. Patients receiving dihydrostreptomycin should be monitored for signs of these adverse effects.
Resistance[edit | edit source]
Bacterial resistance to dihydrostreptomycin can occur through various mechanisms, including the modification of the antibiotic target site, enzymatic inactivation, and efflux pump activation. Resistance is a significant concern in the treatment of tuberculosis, necessitating the use of combination therapy to prevent the development of resistant strains.
History[edit | edit source]
Dihydrostreptomycin was developed as a derivative of streptomycin to improve its pharmacological properties. It was first introduced in the 1940s and has since been used in the treatment of various bacterial infections. However, due to its side effects and the development of resistance, its use has declined in favor of newer antibiotics.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
