Prulifloxacin

Prulifloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections. It is a prodrug which is metabolized in the body into the active drug ulifloxacin.

Pharmacology

Prulifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It works by inhibiting the bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination.

Clinical Use

Prulifloxacin is used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, and skin and soft tissue infections. It is also used in the treatment of gastroenteritis caused by susceptible bacteria.

Side Effects

Like other fluoroquinolones, prulifloxacin can cause side effects, including nausea, diarrhea, and allergic reactions. Rare but serious side effects include tendon rupture, QT prolongation, and Clostridium difficile infection.

Drug Interactions

Prulifloxacin can interact with other medications, including antacids, iron supplements, and multivitamins containing zinc or iron. These can bind to prulifloxacin and reduce its absorption, making it less effective.

See Also

• Fluoroquinolone
• Antibiotic resistance
• Pharmacokinetics

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