Rolitetracycline

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Rolitetracycline.svg

Antibiotic

Rolitetracycline

Rolitetracycline


Trade names Reverin


Chemical nomenclature
IUPAC name (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide



Routes Intramuscular, Intravenous







Identifiers
CAS Number 751-97-3
PubChem 5281054
DrugBank DB00459
ChemSpider 4447650
UNII 0D3Q044KCA
KEGG D02368
ChEMBL 1201201
Chemical data


Chemical formula C27H33N3O8


SMILES CN(C)[C@H]1[C@@H]2C(=O)C3=C(C(=O)C=C(C3=C2O)O)C(=C4C[C@@H](C(=O)N(C4)C)O)C1O
InChI 1S/C27H33N3O8/c1-26(37)10-7-15-23(34)20(30(4)5)12-17(32)21(15)27(2,3)11-8-16-22(35)19(31)14(29-9-13(28)33)6-18(16)25(36)24(26)38/h6,8,12,16,18,22,31,34-35,37-38H,7,9-11H2,1-5H3,(H,28,33)/t16-,18-,22-,26-/m0/s1
InChIKey ZQSIJRDFPHDXIC-UBUQANBQSA-N


Rolitetracycline is a tetracycline antibiotic used to treat various bacterial infections. It is a semisynthetic derivative of tetracycline and is known for its broad-spectrum activity against a wide range of gram-positive and gram-negative bacteria.

Mechanism of Action[edit]

Rolitetracycline works by inhibiting bacterial protein synthesis. It binds to the 30S ribosomal subunit of the bacteria, preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This action inhibits the addition of new amino acids to the growing peptide chain, effectively stopping bacterial growth and replication.

Pharmacokinetics[edit]

Rolitetracycline can be administered via intramuscular or intravenous routes. It is well-absorbed and distributed throughout the body, including the cerebrospinal fluid, making it effective in treating central nervous system infections. The drug is metabolized in the liver and excreted primarily through the kidneys.

Clinical Uses[edit]

Rolitetracycline is used to treat a variety of infections, including:

Side Effects[edit]

Common side effects of rolitetracycline include:

Contraindications[edit]

Rolitetracycline should not be used in patients with:

Precautions[edit]

  • Use with caution in patients with a history of allergic reactions to antibiotics.
  • Avoid use in pregnant and breastfeeding women due to potential adverse effects on the fetus and infant.
  • Monitor liver and kidney function during prolonged therapy.

See Also[edit]

References[edit]


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