Rolitetracycline
Antibiotic
| Rolitetracycline | |
|---|---|
|
| |
| Trade names | Reverin
|
| Chemical nomenclature | |
| IUPAC name | (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
|
| Routes | Intramuscular, Intravenous
|
| Identifiers | |
| CAS Number | 751-97-3 |
| PubChem | 5281054 |
| DrugBank | DB00459 |
| ChemSpider | 4447650 |
| UNII | 0D3Q044KCA |
| KEGG | D02368 |
| ChEMBL | 1201201 |
| Chemical data
| |
| Chemical formula | C27H33N3O8
|
| SMILES | CN(C)[C@H]1[C@@H]2C(=O)C3=C(C(=O)C=C(C3=C2O)O)C(=C4C[C@@H](C(=O)N(C4)C)O)C1O
|
| InChI | 1S/C27H33N3O8/c1-26(37)10-7-15-23(34)20(30(4)5)12-17(32)21(15)27(2,3)11-8-16-22(35)19(31)14(29-9-13(28)33)6-18(16)25(36)24(26)38/h6,8,12,16,18,22,31,34-35,37-38H,7,9-11H2,1-5H3,(H,28,33)/t16-,18-,22-,26-/m0/s1
|
| InChIKey | ZQSIJRDFPHDXIC-UBUQANBQSA-N
|
Rolitetracycline is a tetracycline antibiotic used to treat various bacterial infections. It is a semisynthetic derivative of tetracycline and is known for its broad-spectrum activity against a wide range of gram-positive and gram-negative bacteria.
Mechanism of Action[edit]
Rolitetracycline works by inhibiting bacterial protein synthesis. It binds to the 30S ribosomal subunit of the bacteria, preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This action inhibits the addition of new amino acids to the growing peptide chain, effectively stopping bacterial growth and replication.
Pharmacokinetics[edit]
Rolitetracycline can be administered via intramuscular or intravenous routes. It is well-absorbed and distributed throughout the body, including the cerebrospinal fluid, making it effective in treating central nervous system infections. The drug is metabolized in the liver and excreted primarily through the kidneys.
Clinical Uses[edit]
Rolitetracycline is used to treat a variety of infections, including:
- Respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Gastrointestinal infections
- Sexually transmitted infections
Side Effects[edit]
Common side effects of rolitetracycline include:
- Gastrointestinal disturbances such as nausea, vomiting, and diarrhea
- Photosensitivity
- Allergic reactions including rash and anaphylaxis
- Hepatotoxicity
- Nephrotoxicity
Contraindications[edit]
Rolitetracycline should not be used in patients with:
- Known hypersensitivity to tetracyclines
- Severe liver dysfunction
- Severe kidney dysfunction
Precautions[edit]
- Use with caution in patients with a history of allergic reactions to antibiotics.
- Avoid use in pregnant and breastfeeding women due to potential adverse effects on the fetus and infant.
- Monitor liver and kidney function during prolonged therapy.
See Also[edit]
References[edit]
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