Rolitetracycline

Rolitetracycline is a tetracycline antibiotic. It is a prodrug which is converted in the body to tigecycline, and is used in the treatment of various bacterial infections.

Pharmacology

Rolitetracycline is a broad-spectrum antibiotic that is active against a wide variety of bacteria. However, some strains of bacteria have developed resistance to this antibiotic, which has reduced its effectiveness for treating some types of infections.

Mechanism of action

Rolitetracycline works by inhibiting the synthesis of proteins in bacteria, preventing them from growing and multiplying. It does this by binding to the 30S ribosomal subunit in the bacterial cell, preventing the addition of amino acids to the growing peptide chain.

Side effects

Common side effects of rolitetracycline include nausea, vomiting, diarrhea, and loss of appetite. More serious side effects may include allergic reactions, liver damage, and changes in blood counts.

History

Rolitetracycline was first synthesized in the 1950s and has been used in clinical practice since the 1960s. It is a derivative of chlorotetracycline.

See also

• Tetracycline antibiotics
• Tigecycline
• Chlorotetracycline

Rolitetracycline Resources
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