Azidamfenicol

Azidamfenicol is a chemical compound that belongs to the class of organic compounds known as phenols. It is a synthetic antibacterial agent that is structurally related to chloramphenicol and thiamphenicol.

Chemistry[edit | edit source]

Azidamfenicol is a white to off-white crystalline powder. It is soluble in water and alcohol, and slightly soluble in chloroform and ether. The chemical formula of azidamfenicol is C11H12N4O5.

Pharmacology[edit | edit source]

Azidamfenicol works by inhibiting protein synthesis in bacteria, thereby stopping their growth. It binds to the 50S subunit of the bacterial ribosome, preventing the addition of new amino acids to the growing peptide chain.

Medical Uses[edit | edit source]

Azidamfenicol is used in the treatment of various bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. It is also used in the treatment of typhoid fever and ocular infections.

Side Effects[edit | edit source]

Common side effects of azidamfenicol include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause serious side effects such as bone marrow suppression, anemia, and allergic reactions.

Precautions[edit | edit source]

Patients with a history of allergy to azidamfenicol or other phenicol antibiotics should not use this medication. It should also be used with caution in patients with liver disease or kidney disease.

Interactions[edit | edit source]

Azidamfenicol may interact with other medications, including anticoagulants, oral contraceptives, and antifungal medications. Therefore, patients should inform their healthcare provider about all the medications they are currently taking.