Cefodizime

Cefodizime

Cefodizime is a third-generation cephalosporin antibiotic. It is primarily used in the treatment of bacterial infections caused by susceptible organisms. Cefodizime is known for its extended spectrum of activity and high efficacy against Gram-negative bacteria, including Pseudomonas aeruginosa and Enterobacteriaceae.

Pharmacology

Cefodizime, like other cephalosporins, works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis.

Clinical Use

Cefodizime is used in the treatment of various types of infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and bone and joint infections. It is also used in the treatment of septicemia, meningitis, and other serious infections caused by susceptible strains of bacteria.

Side Effects

Common side effects of Cefodizime include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause serious side effects such as Clostridium difficile-associated diarrhea, Stevens-Johnson syndrome, and anaphylaxis.

Resistance

Resistance to Cefodizime and other cephalosporins can occur through several mechanisms, including the production of beta-lactamase enzymes, alteration of PBPs, and changes in outer membrane proteins.

See Also

• Cephalosporin
• Antibiotic resistance
• Penicillin-binding proteins

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