Succinylsulfathiazole
An antibiotic used in the treatment of intestinal infections
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Succinylsulfathiazole is a sulfonamide antibiotic primarily used in the treatment of intestinal infections. It is a derivative of sulfathiazole, modified to improve its pharmacokinetic properties, particularly its absorption and distribution in the gastrointestinal tract.
Mechanism of Action[edit | edit source]
Succinylsulfathiazole works by inhibiting the synthesis of folic acid in bacteria. It competes with para-aminobenzoic acid (PABA) for the active site of the enzyme dihydropteroate synthase, which is crucial for the production of folic acid. This inhibition leads to a decrease in bacterial growth and replication, effectively controlling the infection.
Pharmacokinetics[edit | edit source]
Succinylsulfathiazole is designed to remain largely within the gastrointestinal tract, minimizing systemic absorption. This property makes it particularly useful for treating infections localized to the intestines, such as bacterial dysentery and enteritis.
Clinical Uses[edit | edit source]
Succinylsulfathiazole is indicated for the treatment of various intestinal infections, including:
Side Effects[edit | edit source]
Common side effects of succinylsulfathiazole include:
Contraindications[edit | edit source]
Succinylsulfathiazole should not be used in individuals with a known hypersensitivity to sulfonamides. It is also contraindicated in patients with severe renal impairment or hepatic impairment.
Related pages[edit | edit source]
Succinylsulfathiazole[edit | edit source]
Succinylsulfathiazole
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