Gemifloxacin
Gemifloxacin[edit | edit source]
Gemifloxacin represents a prominent fourth-generation oral fluoroquinolone antibiotic. It is predominantly used in treating mild-to-moderate respiratory tract infections instigated by susceptible organisms.
Mechanism of Action[edit | edit source]
Gemifloxacin, like its fluoroquinolone counterparts, boasts an expansive activity spectrum against aerobic gram-positive and gram-negative organisms. Its mechanism of action primarily revolves around inhibiting type II DNA topoisomerases (gyrases). These enzymes are instrumental in synthesizing bacterial mRNAs (transcription) and DNA replication.
FDA Approval Information[edit | edit source]
The FDA sanctioned the medical use of Gemifloxacin in the United States in the year 2003. However, its adoption rate has been somewhat overshadowed by other more commonly used fluoroquinolones, such as ciprofloxacin and levofloxacin. As of current medical directives, Gemifloxacin is prescribed for conditions like acute exacerbations of chronic bronchitis and community-acquired pneumonia.
Dosage and Administration[edit | edit source]
Gemifloxacin is commercially available under the brand name 'Factive' and is dispensed in 320 mg tablet form. The recommended dosage for patients is 320 mg, administered once daily, spanning 5 to 7 days.
Side Effects[edit | edit source]
Like any therapeutic drug, Gemifloxacin comes with its set of side effects. Some common side effects experienced by users include:
Moreover, while less frequent, certain severe side effects associated with the fluoroquinolones class have been reported. These encompass:
- prolongation of the QT interval
- seizures
- hallucinations
- tendon rupture
- angioedema
- photosensitivity
Liver Safety[edit | edit source]
While Gemifloxacin is predominantly safe, it has, in rare circumstances, been associated with instances of acute liver injury.
See Also[edit | edit source]
| Gemifloxacin Resources | |
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List of flouroquinolones[edit source]
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