Severe cutaneous adverse reactions

Severe Cutaneous Adverse Reactions (SCARs) are a group of severe skin reactions that are often associated with medication use. These reactions can range from mild to life-threatening and include conditions such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Etiology

SCARs are typically caused by an adverse reaction to medications. The most common drugs associated with SCARs include antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, and allopurinol. However, any medication can potentially cause a SCAR.

Pathophysiology

The exact pathophysiology of SCARs is not fully understood. It is believed to involve a complex interaction between the drug, the immune system, and the skin. In some cases, the drug may directly damage the skin cells, leading to cell death and the release of inflammatory mediators. In other cases, the drug may trigger an immune response, leading to inflammation and tissue damage.

Clinical Presentation

The clinical presentation of SCARs can vary widely, depending on the specific type of reaction. Common symptoms include a rash, fever, and involvement of internal organs. In severe cases, the skin may blister and peel off, leading to significant morbidity and mortality.

Diagnosis

Diagnosis of SCARs is primarily based on clinical presentation and history of drug exposure. Laboratory tests, skin biopsy, and immunological tests may also be used to support the diagnosis.

Treatment

The primary treatment for SCARs is discontinuation of the offending drug. Supportive care, including wound care and management of systemic symptoms, is also important. In some cases, immunosuppressive therapy may be used to control the immune response.

Prognosis

The prognosis of SCARs can vary widely, depending on the severity of the reaction and the patient's overall health. With prompt recognition and treatment, most patients can recover fully. However, severe reactions can be life-threatening and may result in long-term complications.

See Also

• Drug Allergy
• Drug-induced Skin Reactions
• Immunology
• Dermatology

Severe cutaneous adverse reactions Resources
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