WAY-100,135

WAY-100,135

WAY-100,135 is a chemical compound that acts as a selective antagonist of the 5-HT_1A receptor, a subtype of the serotonin receptor. It is primarily used in scientific research to study the role of 5-HT_1A receptors in various physiological and neurological processes.

Chemical Structure and Properties

WAY-100,135 is a phenylpiperazine derivative. Its chemical structure is characterized by a piperazine ring attached to a phenyl group, which is further substituted with other functional groups that confer its selectivity for the 5-HT_1A receptor.

• IUPAC Name: 4-(2'-Methoxyphenyl)-1-[2'-(n-2-pyridinyl)ethyl]piperazine
• Molecular Formula: C₁₉H₂₄N₂O
• Molecular Weight: 296.41 g/mol

Mechanism of Action

WAY-100,135 functions as an antagonist at the 5-HT_1A receptor. This means it binds to the receptor without activating it, thereby blocking the action of serotonin (5-HT) and other agonists. The 5-HT_1A receptor is a G protein-coupled receptor (GPCR) that is involved in the regulation of mood, anxiety, and other central nervous system functions.

Research Applications

WAY-100,135 is used extensively in research to explore the physiological and behavioral effects of 5-HT_1A receptor modulation. Some key areas of research include:

• Anxiety and Depression: Studies using WAY-100,135 help elucidate the role of 5-HT_1A receptors in anxiety and depression, providing insights into potential therapeutic targets.
• Neuropharmacology: It is used to investigate the interaction of serotonin with other neurotransmitter systems and its impact on brain function.
• Behavioral Studies: Researchers use WAY-100,135 to study the effects of 5-HT_1A receptor antagonism on animal behavior, including social interaction, stress response, and learning.

Pharmacokinetics

The pharmacokinetic profile of WAY-100,135 includes its absorption, distribution, metabolism, and excretion characteristics. However, detailed pharmacokinetic data is often specific to the experimental conditions and the species being studied.

Safety and Toxicology

As a research chemical, WAY-100,135 is not intended for human use. Safety and toxicology data are primarily derived from animal studies, and researchers must handle it with appropriate precautions in a laboratory setting.

Also see

• 5-HT1A receptor
• Serotonin receptor
• Neuropharmacology
• Anxiety disorders
• Depression (mood disorder)