WDR75

WDR75

WDR75 is a protein-coding gene that is found in humans. It is also known as WD repeat domain 75 and is located on chromosome 1. The gene is conserved across different species, indicating its importance in biological processes.

Gene Structure

The WDR75 gene consists of 14 exons and spans approximately 20 kilobases. It encodes a protein that contains multiple WD40 repeat domains. WD40 repeats are known to mediate protein-protein interactions and are involved in various cellular processes.

Function

The exact function of WDR75 is not yet fully understood. However, studies have suggested its involvement in several cellular processes. It has been implicated in DNA repair, cell cycle regulation, and chromatin remodeling. WDR75 may also play a role in gene expression and transcriptional regulation.

Clinical Significance

Mutations in the WDR75 gene have been associated with certain genetic disorders. For example, mutations in WDR75 have been found in individuals with intellectual disability and developmental delay. These findings suggest that WDR75 is crucial for normal brain development and function.

Interactions

WDR75 has been shown to interact with several other proteins. For instance, it interacts with components of the DNA repair machinery, suggesting its involvement in DNA damage response pathways. It has also been found to interact with chromatin remodeling complexes, indicating its role in regulating gene expression.

See Also

• Chromosome 1
• Protein-coding gene
• WD40 repeat
• Intellectual disability
• Developmental delay