YM-254890

From WikiMD's Wellness Encyclopedia

YM-254890 is a G protein-coupled receptor antagonist that is derived from the bacterium Chromobacterium violaceum. It is a highly selective inhibitor of the Gq alpha subunit of the G protein, and it has been used in the study of G protein signaling.

Structure and Function[edit | edit source]

The structure of YM-254890 is unique among G protein antagonists. It is a cyclic depsipeptide, meaning it contains both peptide and ester bonds. The molecule has a complex structure that includes a 22-membered ring and several unusual amino acids.

YM-254890 functions by binding to the Gq alpha subunit of the G protein, preventing it from interacting with G protein-coupled receptors on the cell surface. This inhibits the activation of the G protein and the subsequent intracellular signaling pathways it would normally initiate.

Pharmacological Applications[edit | edit source]

Because of its specificity for the Gq alpha subunit, YM-254890 has been used in research to study the role of this protein in various cellular processes. It has been particularly useful in studying G protein-coupled receptor signaling, as it allows researchers to selectively inhibit this pathway and observe the resulting effects on the cell.

In addition to its research applications, YM-254890 has potential therapeutic applications. Its ability to inhibit G protein signaling could make it useful in the treatment of diseases that are caused by overactive G protein-coupled receptor signaling, such as certain types of cancer.

See Also[edit | edit source]

References[edit | edit source]



WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD