YM-348

YM-348 is a 5-HT1A receptor agonist that was developed by Yamanouchi Pharmaceutical for the treatment of anxiety and depression. It has anxiolytic and antidepressant effects in animal studies, but was never marketed.

Pharmacology

YM-348 is a potent and selective 5-HT1A receptor agonist, with a Ki of 0.8 nM at the 5-HT1A receptor, and 660 nM at the 5-HT2A receptor, giving it around 800x selectivity for the 5-HT1A receptor. It also has moderate affinity for the alpha-1 adrenergic receptor and D2 receptor, but these are unlikely to be clinically significant at therapeutic doses.

Clinical trials

YM-348 was investigated in clinical trials for the treatment of anxiety and depression, but development was discontinued and it was never marketed.

See also

• 5-HT1A receptor
• 5-HT2A receptor
• Yamanouchi Pharmaceutical
• Anxiety
• Depression

References

YM-348 Resources
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