ZBTB33

ZBTB33 (Zinc Finger and BTB Domain Containing 33), also known as KAISO, is a protein that in humans is encoded by the ZBTB33 gene. This protein plays a crucial role in cellular processes such as DNA binding, transcriptional regulation, and cell cycle progression.

Function

ZBTB33 is a transcriptional regulator that binds methylated DNA. It can bind to the promoter of the TGF-beta1 gene and repress its transcription. The protein is also involved in the regulation of the Wnt signaling pathway. It can act as a tumor suppressor and may play a role in colorectal cancer.

Structure

The ZBTB33 protein contains a BTB/POZ domain, which is involved in protein-protein interactions, and a zinc finger domain, which is responsible for DNA binding. The protein is located in the nucleus of the cell.

Clinical significance

Mutations in the ZBTB33 gene have been associated with various types of cancer, including colorectal cancer and breast cancer. The protein's role as a tumor suppressor makes it a potential target for cancer therapy.

See also

• Zinc finger
• BTB/POZ domain
• TGF-beta
• Wnt signaling pathway
• Colorectal cancer
• Breast cancer