ZNF148

ZNF148, also known as Zinc Finger Protein 148, is a protein that in humans is encoded by the ZNF148 gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains are known to bind to DNA, RNA, protein and/or lipid substrates.

Function

ZNF148 is a transcription factor that can both activate and repress transcription in a context-dependent manner. It is involved in the regulation of several genes including cytokine genes, growth factor genes, and genes that are involved in cell adhesion and cell cycle regulation.

Structure

The ZNF148 protein contains several zinc finger domains. These domains are characterized by the presence of a zinc ion coordinated by cysteine and histidine residues. The zinc finger domains of ZNF148 are involved in binding to DNA, RNA, protein and/or lipid substrates.

Clinical significance

Mutations in the ZNF148 gene have been associated with a variety of diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. In particular, ZNF148 has been implicated in the development of colorectal cancer, breast cancer, and lung cancer.

Research

Research into the function and regulation of ZNF148 is ongoing. Current areas of focus include understanding the role of ZNF148 in cell proliferation, cell differentiation, and apoptosis, as well as its potential as a therapeutic target in cancer and other diseases.

See also

• Zinc finger
• Transcription factor
• Gene
• Protein

References

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