ZNF281

ZNF281 is a gene that encodes a zinc finger protein in Homo sapiens. The protein encoded by this gene is a transcription factor that can bind to DNA and regulate gene expression.

Function

ZNF281 is a transcription factor that plays a crucial role in the regulation of gene expression. It is involved in various biological processes, including cell differentiation, cell proliferation, and apoptosis. The protein encoded by this gene has been found to interact with other proteins, such as p53 and E2F1, to regulate the expression of target genes.

Clinical significance

Mutations in the ZNF281 gene have been associated with several types of cancer, including breast cancer, colorectal cancer, and gastric cancer. Studies have shown that overexpression of ZNF281 can promote tumor growth and metastasis, while downregulation of ZNF281 can inhibit tumor growth and induce apoptosis.

Research

Research on ZNF281 is ongoing, with studies focusing on its role in cancer development and progression, as well as its potential as a therapeutic target for cancer treatment.

See also

• Zinc finger protein
• Transcription factor
• Gene expression
• Cancer

References

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