E2F1

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

E2F1 is a protein that in humans is encoded by the E2F1 gene. It is a member of the E2F family of transcription factors, which play a crucial role in controlling the cell cycle and the action of tumor suppressor proteins. E2F1 is also believed to be important in the regulation of gene expression required for the S phase of the cell cycle.

Function[edit | edit source]

E2F1 is a transcription factor that forms a heterodimer with DP1, a regulatory protein. This complex binds to the E2F responsive element, leading to the activation of E2F-responsive genes. These genes are primarily involved in cell cycle regulation and DNA synthesis. E2F1 is also known to induce apoptosis, or programmed cell death, under certain conditions.

Role in Cancer[edit | edit source]

Abnormal regulation of E2F1 has been implicated in the development of several types of cancer. Overexpression of E2F1 can lead to uncontrolled cell proliferation, a hallmark of cancer. Conversely, loss of E2F1 function can also contribute to cancer development by disrupting normal cell cycle regulation.

Clinical Significance[edit | edit source]

Given its role in cell cycle regulation and cancer, E2F1 is a potential target for cancer therapy. Several drugs that inhibit E2F1 activity are currently under investigation. Additionally, E2F1 levels can serve as a prognostic marker in certain types of cancer.

See Also[edit | edit source]

References[edit | edit source]


Stub icon
   This article is a medical stub. You can help WikiMD by expanding it!


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP1 injections in NYC from $125 and up biweekly

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.

Why choose W8MD?

Book Your Appointment

Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD