ZNF41

ZNF41 (Zinc Finger Protein 41) is a protein that in humans is encoded by the ZNF41 gene. This protein is a member of the krueppel C2H2-type zinc-finger protein family, and it functions as a transcription factor to regulate gene expression.

Function

The ZNF41 protein is a nuclear protein that binds to DNA through its zinc-finger domains, which are common DNA-binding domains found in many transcription factors. The protein acts as a transcriptional repressor, meaning it inhibits the transcription of certain genes. This regulation of gene expression is crucial for many biological processes, including cell differentiation, development, and homeostasis.

Clinical Significance

Mutations in the ZNF41 gene have been associated with X-linked mental retardation (XLMR). XLMR is a condition characterized by significantly below-average overall intellectual functioning and deficits in two or more adaptive behaviors. Studies have shown that a loss of function mutation in the ZNF41 gene can lead to this condition.

Structure

The ZNF41 protein contains several C2H2-type zinc fingers. These are sequences of amino acids that form a stable, finger-like structure, held together by a zinc ion. Each zinc finger can bind to a specific sequence of DNA, allowing the protein to recognize and bind to specific genes.

See Also

• Zinc finger
• Transcription factor
• X-linked mental retardation